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KMID : 0352819930090010081
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Kosin Medical Journal
1993 Volume.9 No. 1 p.81 ~ p.90
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SomatotrophPituitary Adenoma associated with Hyperprolactinemia - A case report with emphasis on the ultrastructural features-
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Abstract
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Pituitary adenoma has become not uncommon tumors because of ecent advances in diagnostic radilogic techniques and surgical approach. However, it has been difficult to correlate microscopic features with hormonal function in these tumors. Although
immunohistochemistry and ultrastructural studies play crucial roles for the morphofunctional classification of the pituitary tumors, light and electron microscopic features may be diagnostic in some cases.
We experienced a case of pituitary adenoma with elevation of both growth hormone and prolactin in a 22-year-old female, who had headeche, lowered visualacuity, golactorrhea, and symptoms of acromegaly-amenorrhea syndrome. The tumor cells are
chromophobic with PAS-orange G stain. With electron microscopy, the tumor cells are characterized be sparse granularity, frequent fibrous bodies enmashing secretory granules, and prominent RER without nebinkrn formation. Frank evidences of
misplaced
exocytosis and alterations of mitochondria are not seen.
We report this case withan emphasis on the diagnostic application of ultrastructural examination in the pituitary adenoma.
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